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Review
. 2015 Jul 2;11(7):e1004904.
doi: 10.1371/journal.ppat.1004904. eCollection 2015 Jul.

Extracellular Virions: The Advance Guard of Poxvirus Infections

David J Pickup  1
Affiliations
Review

Extracellular Virions: The Advance Guard of Poxvirus Infections

David J Pickup. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Fig 1
Fig 1. The advance guard model of poxvirus infection.
EVs are actively released from intact infected cells and propelled from those cells to outpace the spread of antiviral cytokines, interferons, proinflammatory cytokines, PAMPs, and DAMPs, which are subsequently released from infected cells, and which may initiate innate immune responses from resident or infiltrating sentinel cells. This mechanism may also enable productive infections of neighboring cells that might otherwise be rendered refractive to viral replication by interferons and danger signals released from cells at the site of the primary infection. Cell-associated EVs carried long distances from the primary site of infection by motile cells may similarly be able to initiate infections in the absence of accompanying danger signals.
See this image and copyright information in PMC

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