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. 2015 May;9(5):1944-1946.
doi: 10.3892/etm.2015.2307. Epub 2015 Feb 24.

Severe airflow obstruction in a patient with ulcerative colitis and toxic epidermal necrolysis: A case report

Shijima Taguchi  1 , Junichi Furuta  2 , Gen Ohara  3 , Katsunori Kagohashi  3 , Hiroaki Satoh  3
Affiliations

Severe airflow obstruction in a patient with ulcerative colitis and toxic epidermal necrolysis: A case report

Shijima Taguchi et al. Exp Ther Med. 2015 May.

Abstract

Bronchiolitis is a rare condition mainly affecting the intralobular conducting and transitional small airways. The present study describes a case of severe airflow limitation in a patient with ulcerative colitis who developed toxic epidermal necrolysis following mesalazine therapy. Forced expiratory volume in one second was decreased and a flow-volume curve showed airflow limitation, but the single-breath diffusing capacity of the lung for carbon monoxide (DLCO) and DLCO divided by alveolar volume (DLCO/VA) were not decreased. This rare clinical condition should be considered as a differential diagnosis for subjects presenting with sub-acutely developed airflow obstruction if the findings in chest computed tomography scans demonstrate hyperinflation but few low-attenuation areas. Relatively well-preserved DLCO and DLCO/VA provide a clue to establishing the correct diagnosis.

Keywords: airflow obstruction; mesalazine; obstructive bronchiolitis; toxic epidermal necrolysis; ulcerative colitis.

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Figures

Figure 1.
Figure 1.
Flow-volume curve at the time of presentation to the hospital with dyspnea on effort. *Predicted curve; **measured curve.
Figure 2.
Figure 2.
Slices (A) and (B) of chest computed tomography scan display bronchiectasis and thickening of the walls of the central bronchi in both lungs.
See this image and copyright information in PMC

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