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. 2015 Jul 3:97:e14.
doi: 10.1017/S0016672315000142.

The role of GRIK4 gene in treatment-resistant depression

Elena Milanesi  1 , Cristian Bonvicini  2 , Chiara Congiu  3 , Marco Bortolomasi  4 , Giulio Gainelli  4 , Massimo Gennarelli  2 , Alessandra Minelli  3
Affiliations

The role of GRIK4 gene in treatment-resistant depression

Elena Milanesi et al. Genet Res (Camb). .

Abstract

Several lines of evidence implicate abnormalities in glutamatergic neural transmission in major depressive disorder (MDD) and treatment response. A high percentage of MDD patients do not respond adequately to antidepressants and are classified as having treatment-resistant depression (TRD). In this study we investigated five GRIK4 variants, previously associated with antidepressants response, in an Italian cohort of 247 MDD no-TRD and 380 TRD patients. We found an association between rs11218030 G allele and TRD. Moreover, significant associations between rs11218030 and rs1954787 and the presence of psychotic symptoms were observed. In conclusion, our data support the involvement of GRIK4 in TRD and in the risk of developing psychotic symptoms during depressive episodes.

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Figures

Fig. 1.
Fig. 1.
LD among the investigated SNPs. Dark gray and light gray colours represent a strong LD pattern (D’ >0·8) and white colour represents moderate to low LD (D’ <0·8 to >0·5).
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References

    1. Bentley S. M., Pagalilauan G. L. & Simpson S. (2014). Major depression. The Medical Clinics of North America 98, 981–1005. - PubMed
    1. Blackwood D. H., Pickard B. J., Thomson P. A., Evans K. L., Porteous D. J. & Muir W. J. (2007). Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1. Neurotoxicity Research 11, 73–83. - PubMed
    1. Boyer P., Skolnick P. & Fossom L. H. (1998). Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain. Journal of Molecular Neuroscience 10, 219–233. - PubMed
    1. Carvalho A. F., Berk M., Hyphantis T. N. & McIntyre R. S. (2014). The integrative management of treatment-resistant depression: a comprehensive review and perspectives. Psychotherapy and Psychosomatics 83, 70–88. - PubMed
    1. Catches J. S., Xu J. & Contractor A. (2012). Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice. Behavioural Brain Research 228, 406–414. - PMC - PubMed

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