Dissecting the Role of Smooth Muscle Cells versus Pericytes in Regulating Cerebral Blood Flow Using In Vivo Optical Imaging
- PMID: 26139364
- DOI: 10.1016/j.neuron.2015.06.024
Dissecting the Role of Smooth Muscle Cells versus Pericytes in Regulating Cerebral Blood Flow Using In Vivo Optical Imaging
Abstract
The brain regulates blood flow to match energy demand to nutrient supply. In this issue of Neuron, using in vivo optical imaging and optogenetics, Hill et al. (2015) report that arteriolar smooth muscle cells are key players in regulating cerebral blood flow in the healthy state and contribute to the "no reflow" phenomenon after ischemic stroke.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes.Neuron. 2015 Jul 1;87(1):95-110. doi: 10.1016/j.neuron.2015.06.001. Epub 2015 Jun 25. Neuron. 2015. PMID: 26119027 Free PMC article.
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