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Editorial
. 2015 Jul 3;117(2):109-12.
doi: 10.1161/CIRCRESAHA.117.306851.

MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment

Christina L Papke  1 , Yoshito Yamashiro  1 , Hiromi Yanagisawa  2
Affiliations
Editorial

MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment

Christina L Papke et al. Circ Res. .
No abstract available

Keywords: aorta; extracellular matrix; mutation; myocytes, smooth muscle; osteopontin.

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Figures

Figure
Figure. Loss of MMP17 affects maturation of vascular smooth muscle cell (VSMC) and integrity of the aortic wall
Osteopontin (OPN, blue) is a biologically relevant substrate for MMP17 during aortic development. Cleaved N-terminal Opn (N-OPN), but not full-length OPN, phosphorylates JNK in SMCs and facilitates SMC maturation as well as forms connections to elastic lamina. Loss of MMP17 results in increased susceptibility to angiotensin II (AngII)-induced thoracic aortic aneurysms (TAA).
See this image and copyright information in PMC

Comment on

  • Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.
    Martín-Alonso M, García-Redondo AB, Guo D, Camafeita E, Martínez F, Alfranca A, Méndez-Barbero N, Pollán Á, Sánchez-Camacho C, Denhardt DT, Seiki M, Vázquez J, Salaices M, Redondo JM, Milewicz D, Arroyo AG. Martín-Alonso M, et al. Circ Res. 2015 Jul 3;117(2):e13-26. doi: 10.1161/CIRCRESAHA.117.305108. Epub 2015 May 11. Circ Res. 2015. PMID: 25963716

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