Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Apr;77(2):141-6.
doi: 10.1007/s12262-013-0987-0. Epub 2013 Oct 12.

Ductal Carcinoma In Situ of the Breast

Yash Vaidya  1 , Pradeep Vaidya  2 , Tanvi Vaidya  3
Affiliations
Review

Ductal Carcinoma In Situ of the Breast

Yash Vaidya et al. Indian J Surg. 2015 Apr.

Abstract

Ductal carcinoma in situ (DCIS) of the breast is a potentially invasive neoplasm. Risk factors include high estrogen states such as use of oral contraceptive (OC) pills, nulliparity, advanced age at first birth, and also family history and genetic mutations. The incidence of this usually clinically silent condition has risen in the past few decades due to widespread screening and diagnostic mammography, with final diagnosis confirmed by biopsy. At present, treatment options include total or simple mastectomy or lumpectomy with radiation. Adjuvant therapy includes antiestrogens like tamoxifen and human epidermal growth factor receptor 2 (HER2) suppression therapy. With the latest advances in chemotherapy and better understanding on the pathogenesis of the lesion, it is anticipated that more effective modalities of treatment may soon be available.

Keywords: Ductal carcinoma in situ; Lumpectomy; Mastectomy; NSABP trials.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Mammographs showing lesions
See this image and copyright information in PMC

References

    1. Rosner D, Bedwani RN, Vana J. Noninvasive breast carcinoma. Results of a national survey by the American College of Surgeons. Ann Surg. 1980;192:139–147. doi: 10.1097/00000658-198008000-00001. - DOI - PMC - PubMed
    1. Virnig BA, Tuttle TM, Shamliyan T, Kane RL. Ductal carcinoma in Situ of the breast: a systematic review of incidence, treatment, and outcomes. J Natl Cancer Inst. 2010;102(3):170–178. doi: 10.1093/jnci/djp482. - DOI - PubMed
    1. Brinton LA, Sherman ME, Carreon JD, Anderson WF. Recent trends in breast cancer among younger women in the United States. J Natl Cancer Inst. 2008;100:1643–1648. doi: 10.1093/jnci/djn344. - DOI - PMC - PubMed
    1. Ernster VL, Ballard-Barbash R, Barlow WE, et al. Detection of ductal carcinoma in situ in women undergoing screening mammography. J Natl Cancer Inst. 2002;94:1546–1554. doi: 10.1093/jnci/94.20.1546. - DOI - PubMed
    1. May DS, Lee NC, Richardson LC, Giustozzi AG, Bobo JK. Mammography and breast cancer detection by race and Hispanic ethnicity: results from a national program (United States) Cancer Causes Control. 2000;11:697–705. doi: 10.1023/A:1008900220924. - DOI - PubMed

LinkOut - more resources