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. 2016;30(10):1144-9.
doi: 10.1080/14786419.2015.1046132. Epub 2015 Jul 3.

Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph

Hong-Mei Chen  1 , Yu-Ting Yang  1 , Hong-Xiang Li  1 , Zhi-Xing Cao  1 , Xiao-Mei Dan  1 , Ling Mei  1 , Da-Le Guo  1 , Chuan-Xia Song  1 , Yu Dai  1 , Jia Hu  1 , Yun Deng  1
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Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph

Hong-Mei Chen et al. Nat Prod Res. 2016.

Abstract

A new monoterpenoid indole alkaloid compound (1) and six known monoterpenoid indole alkaloids compounds (2-7) were isolated from the barks of Voacanga africana Staph. The structures were established by spectral analysis as ibogamine-16-carboxylic acid,17,20-didehydro-5,6-dioxo-10-methoxy-methyl ester (1), voacamine (2), vobasine (3), voacangine (4), voacristine (5), 19-epi-voacristine (6) and 19-epi-heyneanine (7). Compound 1 was confirmed by X-ray crystallographic analysis. All of the isolated compounds were evaluated for cytotoxicity against five cell lines (HEPG-2, A375, MDA-MB-231, SH-SY5Y, CT26). Among them, compounds 2 and 6 displayed significant inhibitory activities, compounds 3, 4 and 5 showed moderate inhibitory activities, while compounds 1 and 7 showed no inhibitory activities against the five cell lines.

Keywords: Voacanga africana Staph; cytotoxicity; monoterpenoid indole alkaloids.

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