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Meta-Analysis
. 2016 Jul 1;80(1):40-52.
doi: 10.1016/j.biopsych.2015.05.014. Epub 2015 Jun 1.

Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

Michael R Irwin  1 , Richard Olmstead  2 , Judith E Carroll  2
Affiliations
Meta-Analysis

Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

Michael R Irwin et al. Biol Psychiatry. .

Abstract

Background: Sleep disturbance is associated with inflammatory disease risk and all-cause mortality. Here, we assess global evidence linking sleep disturbance, sleep duration, and inflammation in adult humans.

Methods: A systematic search of English language publications was performed, with inclusion of primary research articles that characterized sleep disturbance and/or sleep duration or performed experimental sleep deprivation and assessed inflammation by levels of circulating markers. Effect sizes (ES) and 95% confidence intervals (CI) were extracted and pooled using a random effect model.

Results: A total of 72 studies (n > 50,000) were analyzed with assessment of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNFα). Sleep disturbance was associated with higher levels of CRP (ES .12; 95% CI = .05-.19) and IL-6 (ES .20; 95% CI = .08-.31). Shorter sleep duration, but not the extreme of short sleep, was associated with higher levels of CRP (ES .09; 95% CI = .01-.17) but not IL-6 (ES .03; 95% CI: -.09 to .14). The extreme of long sleep duration was associated with higher levels of CRP (ES .17; 95% CI = .01-.34) and IL-6 (ES .11; 95% CI = .02-20). Neither sleep disturbances nor sleep duration was associated with TNFα. Neither experimental sleep deprivation nor sleep restriction was associated with CRP, IL-6, or TNFα. Some heterogeneity among studies was found, but there was no evidence of publication bias.

Conclusions: Sleep disturbance and long sleep duration, but not short sleep duration, are associated with increases in markers of systemic inflammation.

Keywords: Inflammation; Insomnia; Interleukin-6; Meta-analysis; Sleep deprivation; Sleep disturbance; Sleep duration.

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Figures

Figure 1
Figure 1
Forest plot of sleep disturbance associated with inflammation as indexed by C-reactive. Sleep disturbance is assessed by self-reported symptoms and questionnaires. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
Figure 2
Figure 2
Forest plot of sleep disturbance associated with inflammation as indexed by circulating levels of interleukin-6. Sleep disturbance is assessed by self-reported symptoms and questionnaires. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
Figure 3
Figure 3
Forest plot of sleep duration associated with inflammation as indexed by C-reactive. Sleep duration is assessed continuously by subjective and objective measures. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
Figure 4
Figure 4
Forest plot of sleep duration associated with inflammation as indexed by circulating levels of interleukin-6. Sleep duration is assessed continuously by subjective and objective measures. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
Figure 5
Figure 5
Forest plot of sleep duration associated with inflammation as indexed by C-reactive. Sleep duration is assessed categorically with normal sleep being defined by sleep duration 7–8 h per night, and short sleep as < 7 h per night, and long sleep as > 8 h per night. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
Figure 6
Figure 6
Forest plot of sleep duration associated with inflammation as indexed by circulating levels of interleukin-6. Sleep duration is assessed categorically with normal sleep being defined by sleep duration 7–8 h per night, and short sleep as < 7 h per night, and long sleep as > 8 h per night. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
Figure 7
Figure 7
Forest plot of experimentally shortened sleep duration associated with inflammation as indexed by C-reactive. Sleep duration was shortened by either partial- or total night sleep deprivation for one night or for multiple nights. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
Figure 8
Figure 8
Forest plot of experimentally shortened sleep duration associated with inflammation as indexed by circulating levels of interleukin-6. Sleep duration was shortened by either partial- or total night sleep deprivation for one night or for multiple nights. Results are expressed as effect sizes (ES) and 95% confidence intervals (95% CI).
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References

    1. Dew MA, Hoch CC, Buysse DJ, Monk TH, Begely AE, Houck PR, Hall M, Kupper DJ, Reynold CF. Healthy older adults’ sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom Med. 2003;65:63–73. - PubMed
    1. Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry. 2002;59:131–6. - PubMed
    1. Mallon L, Broman JE, Hetta J. Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. J Intern Med. 2002;251:207–16. - PubMed
    1. Vgontzas AN, Fernandez-Mendoza J, Liao D, Bixler EO. Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder. Sleep Med Rev. 2013;17:241–54. - PMC - PubMed
    1. LeBlanc M, Merette C, Savard J, Ivers H, Baillargeon L, Morin CM. Incidence and risk factors of insomnia in a population-based sample. Sleep. 2009;32:1027–37. - PMC - PubMed