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. 2015 Aug 28:101:266-73.
doi: 10.1016/j.ejmech.2015.06.045. Epub 2015 Jun 29.

Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity

Hardeep Kaur  1 , Marta Machado  2 , Carmen de Kock  3 , Peter Smith  3 , Kelly Chibale  4 , Miguel Prudêncio  2 , Kamaljit Singh  5
Affiliations

Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity

Hardeep Kaur et al. Eur J Med Chem. .

Abstract

A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection.

Keywords: Antiplasmodial agents; Blood stage activity; Hybrid drugs; Liver stage activity; Primaquine; Pyrimidine.

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