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Editorial
. 2015 Jun 20;6(17):14729-30.
doi: 10.18632/oncotarget.4411.

ATM in senescence

Katherine M Aird  1 , Rugang Zhang  1
Affiliations
Editorial

ATM in senescence

Katherine M Aird et al. Oncotarget. .
No abstract available

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Figures

Figure 1
Figure 1. ATM inactivation overcomes replication stress-induced senescence
In cells with functional ATM, replication stress induces senescence. In cells without ATM, there is a coordinated upregulation of c-MYC and downregulation of p53 to increase glucose and glutamine utilization. Additionally, decreased p53 increases activity of the pentose phosphate pathway (PPP). This reprogramming in cellular metabolism increases dNTPs, which allows for cells to overcome the senescence-associated cell growth arrest to proliferate.
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