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. 2015 Aug;21(8):863-5.
doi: 10.1038/nm.3891. Epub 2015 Jul 6.

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Mark J W Hanssen  1 , Joris Hoeks  1 , Boudewijn Brans  2 , Anouk A J J van der Lans  1 , Gert Schaart  3 , José J van den Driessche  1 , Johanna A Jörgensen  1 , Mark V Boekschoten  4 , Matthijs K C Hesselink  3 , Bas Havekes  5 , Sander Kersten  4 , Felix M Mottaghy  6 , Wouter D van Marken Lichtenbelt  1 , Patrick Schrauwen  1
Affiliations

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Mark J W Hanssen et al. Nat Med. 2015 Aug.

Abstract

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.

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