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Observational Study
. 2015 Sep;28(6):792-9.
doi: 10.1002/ca.22590. Epub 2015 Jul 16.

Meniscal extrusion or subchondral damage characterize incident accelerated osteoarthritis: Data from the Osteoarthritis Initiative

Jeffrey B Driban  1 , Robert J Ward  2 , Charles B Eaton  3 , Grace H Lo  4   5 , Lori Lyn Price  6   7 , Bing Lu  8 , Timothy E McAlindon  1
Affiliations
Observational Study

Meniscal extrusion or subchondral damage characterize incident accelerated osteoarthritis: Data from the Osteoarthritis Initiative

Jeffrey B Driban et al. Clin Anat. 2015 Sep.

Abstract

Knee osteoarthritis (KOA) is typically a slowly progressive disorder; however, a subset of knees progress with dramatic rapidity. We aimed to describe magnetic resonance imaging (MRI) findings that are associated with accelerated KOA. We conducted a longitudinal descriptive study in the Osteoarthritis Initiative cohort. We selected participants who had no radiographic KOA at baseline with one of the following in the most severe knee: (1) accelerated KOA (progressed to end-stage KOA within 48 months), (2) common KOA, and (3) no KOA at all visits. We enriched the sample by selecting knees with a self-reported or suspected knee injury. A musculoskeletal radiologist blinded to group assignments but not to time sequence performed MRI readings for the visit before and after an injury. We assessed 38 participants (knees), 66% were female, mean age 61 (9) years, and mean body mass index 28.5 (4.9) kg/m(2). Fifteen of 20 knees with no or common KOA, had no incident findings consistent with acute damage. Among the 18 knees with accelerated KOA most had incident findings: 13 (72%) had incident medial meniscal pathology with extrusion and 5 (28%) knees had subchondral damage. Incident MRI findings that are associated with incident accelerated KOA are characterized by structural damage that compromises subchondral bone or the function of the meniscus. Recognizing meniscal extrusion and/or change in shape, lateral meniscal tear, or acute subchondral damage may be vital for identifying individuals at risk for accelerated KOA.

Keywords: ligaments; magnetic resonance imaging; meniscus; osteoarthritis.

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Conflict of interest statement

The authors have no other conflicts of interest with regard to this work.

Figures

Figure 1
Figure 1
Selection criteria for study sample.
Figure 2
Figure 2
Example of a knee with accelerated knee osteoarthritis and a self-reported injury between the 0-month and 12-month visit. The knee developed a subchondral medial femoral fracture, medial radial tear with moderate extrusion, and moderate effusion.
See this image and copyright information in PMC

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