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Comment
. 2015 Jul 7;16(1):135.
doi: 10.1186/s13059-015-0707-0.

Interactome analysis brings splicing into focus

Daniel Dominguez  1 , Christopher B Burge  2   3
Affiliations
Comment

Interactome analysis brings splicing into focus

Daniel Dominguez et al. Genome Biol. .

Abstract

The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing.Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract.

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Figures

Fig. 1
Fig. 1
Representation of the interactomes of a prototypical splicing activator, SRSF1, and a prototypical splicing repressor, HNRNPA1. Akerman and colleagues [3] report that activators — which promote exon inclusion (shown at right) — form more interactions with components of the spliceosome than repressors, which promote exon exclusion (left). EJC exon junction complex; hnRNP heterogeneous nuclear ribonucleoprotein; RBM RNA binding motif; SRSF serine/arginine-rich splicing factor
See this image and copyright information in PMC

Comment on

References

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