Comment on

• α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

  Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V. Peelaerts W, et al. Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10. Nature. 2015. PMID: 26061766
• Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

  Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Dettmer U, et al. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. Nat Commun. 2015. PMID: 26076669 Free PMC article.