Mode of insertion of the sucrase-isomaltase complex in the intestinal brush border membrane: implications for the biosynthesis of this stalked intrinsic membrane protein

Abstract

Unlike other intrinsic plasma membrane proteins the sucrase-isomaltase complex is associated with the intestinal brush border membrane through a highly hydrophobic segment located not far from the N-terminal of one subunit (isomaltase). This observation calls for additions and/or modifications to the generally accepted scheme of biosynthesis of plasma membrane intrinsic proteins.