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. 2015 Jul 7;10(7):e0132541.
doi: 10.1371/journal.pone.0132541. eCollection 2015.

SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity

Dawid Lewandowski  1 , Piotr Ruszkowski  2 , Anita Pińska  2 , Grzegorz Schroeder  1 , Joanna Kurczewska  1
Affiliations

SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity

Dawid Lewandowski et al. PLoS One. .

Abstract

Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Modifications of gallic acid enabling its introduction onto the silica surface.
Fig 2
Fig 2. Schematic representation of the procedure used for the synthesis of gallic acid modified SBA-15 mesoporous silica.
Fig 3
Fig 3. Cytotoxic activity against HeLa cell line, calculated for all samples tested.
Fig 4
Fig 4. Cytotoxic activity against KB cell line, calculated for all samples tested.
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