Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2015 Jul 8:5:11961.
doi: 10.1038/srep11961.

Esophageal Squamous Cell Carcinoma and Gastric Cardia Adenocarcinoma Shared Susceptibility Locus in C20orf54: Evidence from Published Studies

Fujiao Duan  1 , Shuli Cui  2 , Chunhua Song  3 , Xia Zhao  1 , Liping Dai  3 , Yong Shen  4
Affiliations
Meta-Analysis

Esophageal Squamous Cell Carcinoma and Gastric Cardia Adenocarcinoma Shared Susceptibility Locus in C20orf54: Evidence from Published Studies

Fujiao Duan et al. Sci Rep. .

Abstract

This study aimed to determine whether C20orf54 rs13042395 polymorphism modify the risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA) in common population. We conducted a systematic literature review and evaluated the quality of included studies based on Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated to estimate the strengths of the associations. 9 articles (10 studies) were identified for synthesis analyses. Overall, the results indicated that the C20orf54 rs13042395 genotype was subtly decrease the risk of ESCC (T vs. C: OR = 0.95; 95%CI = 0.90-0.99; P = 0.02) and the rs13042395 polymorphism was associated with a decreased risk of GCA (T vs. C: OR = 0.95; 95%CI = 0.91-0.98; P < 0.01). The subsets were divided by smoking and drinking status, but none of the genetic comparisons reached statistical significance. Subgroup analysis was also stratified by body mass index (BMI), rs13042395 polymorphism was significantly associated with a subtly decreased cancer risk in under-weight group and normal group, but no association was observed in over-weight group. In conclusion, C20orf54 rs13042395 polymorphism was significantly associated with decreased ESCC and GCA risk especially for the subjects with under-weight or normal.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Flow diagram for screening and identification of relevant studies.
Figure 2
Figure 2. Frequencies of T allele in rs13042395 among controls stratified by ethnicity.
Figure 3
Figure 3. Forest plot of cancer risk associated with C20orf54 rs13042395 for the allele comparison (T vs. C).
Figure 4
Figure 4. Funnel plot of C20orf54 rs13042395 polymorphism and susceptibility to ESCC and GCA for dominant model (CT + TT vs. CC).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Parkin D. M., Bray F., Ferlay J. & Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 55, 74–108 (2005). - PubMed
    1. Wu C. et al.. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet 43, 679–684 (2011). - PubMed
    1. Metzger R., Schneider P. M., Warnecke-Eberz U., Brabender J. & Holscher A. H. Molecular biology of esophageal cancer. Onkologie 27, 200–206 (2004). - PubMed
    1. Hashibe M. et al.. Esophageal cancer in Central and Eastern Europe: tobacco and alcohol. Int J Cancer 120, 1518–1522 (2007). - PubMed
    1. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7–14 June 1994. IARC Monogr Eval Carcinog Risks Hum 61, 1–241 (1994). - PMC - PubMed

Publication types

Substances