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. 2015 Feb 3;4(5):e1002731.
doi: 10.1080/2162402X.2014.1002731. eCollection 2015 May.

The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression

Limo Chen  1 , John V Heymach  1 , F Xiao-Feng Qin  2 , Don L Gibbons  3
Affiliations

The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression

Limo Chen et al. Oncoimmunology. .

Abstract

Epithelial-mesenchymal transition and immunosuppression are crucial for cancer metastasis and treatment resistance. The mechanism by which these distinct processes are co-opted remains incompletely understood. Our recent work has exposed the "dirty affairs" of the 2 at the tumor site, thus calling for a combined therapy to break such a dangerous liaison.

Keywords: epithelial–mesenchymal transition; immunosuppression; miRNA; therapy resistance; tumor microenvironment.

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Figures

Figure 1.
Figure 1.
Dangerous liaison between epithelial–mesenchymal transition and immunosuppression. The microRNA-200–ZEB1 axis instigates the interplay between cancer cells and immune cells in the tumor microenvironment.
See this image and copyright information in PMC

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