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Case Reports
. 2014 Oct 10;2(1):33-5.
doi: 10.14309/crj.2014.76. eCollection 2014 Oct.

Tacrolimus Therapy for Ulcerative Colitis-Associated Post-Colectomy Enteritis

Barret Rush  1 , Landon Berger  1 , Greg Rosenfeld  2 , Brian Bressler  2
Affiliations
Case Reports

Tacrolimus Therapy for Ulcerative Colitis-Associated Post-Colectomy Enteritis

Barret Rush et al. ACG Case Rep J. .

Abstract

Ulcerative colitis (UC)-associated pan-enteritis is a newly identified clinical entity that occurs almost exclusively after colectomy. Characterized by diffuse small bowel mucosal inflammation not compatible with Crohn's disease, the optimal treatment modality for this condition is unknown. Tacrolimus is a potent calcineurin inhibitor that has been successfully used in the treatment of UC. We describe a case of severe refractory pan-enteritis after colectomy for UC that was successfully treated with oral tacrolimus after failing intravenous corticosteroid treatment. Tacrolimus may be a safe and effective treatment modality for diffuse enteritis after colectomy in UC patients.

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Figures

Figure 1
Figure 1
CT scan with contrast showing diffuse bowel wall edema and mesenteric lymphadenopathy. Bowel wall thickening extended throughout the small bowel.
Figure 2
Figure 2
EGD at admission demonstrating severe diffuse enteritis in the duodenum.
See this image and copyright information in PMC

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