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Case Reports
. 2014 Oct 10;2(1):55-7.
doi: 10.14309/crj.2014.84. eCollection 2014 Oct.

Graft-Versus-Host Disease of the Upper Gastrointestinal Tract After an Autologous Stem Cell Transplant

Benjamin Barbash  1 , Scott Kramer  2 , Demetrios Tzimas  2 , Patrick Saitta  2
Affiliations
Case Reports

Graft-Versus-Host Disease of the Upper Gastrointestinal Tract After an Autologous Stem Cell Transplant

Benjamin Barbash et al. ACG Case Rep J. .

Abstract

Graft-versus-host disease (GVHD) in recipients of autologous stem cell transplantation (SCT) is less common compared to recipients of allogeneic SCT, but its existence has been well documented. Similarly, the diarrheal component of the disease is highlighted when discussing its gastrointestinal (GI) manifestations, with less emphasis given to upper GI symptoms like nausea and vomiting. We present a case illustrating the upper GI tract signs and symptoms of GVHD after autologous SCT, and emphasize that prompt treatment can rapidly improve morbidity and prevent disease progression.

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Figures

Figure 1
Figure 1
Duodenal biopsy at (A) 4x, (B) 20x, and (C) 40x magnification showing mucosa with mild reactive change and increased apoptotic activity (up to 6 per 10 consecutive glands/crypts), suggestive of mild or early GVHD.
See this image and copyright information in PMC

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