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Editorial
. 2015 Jun 30;6(18):15722-3.
doi: 10.18632/oncotarget.4652.

Unleashing rapamycin in fibrosis

Alexander T Hillel  1 , Alexander Gelbard  2
Affiliations
Editorial

Unleashing rapamycin in fibrosis

Alexander T Hillel et al. Oncotarget. .
No abstract available

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Figures

Figure 1
Figure 1. Proposed schematic of rapamycin inhibition of fibrosis
Rapamycin binds with FK-binding protein 12 to inhibit the mechanistic Target of Rapamycin (mTOR). Proposed downstream effects of mTOR inhibition on fibroblasts include reduced lipid, nucleotide, and protein biosynthesis which results in decreased size and cell cycle inhibition which results in decreased proliferation. Furthermore, suppression of immune cells and their mediators attenuates inflammation and its resultant stimulatory effect on fibroblasts.
See this image and copyright information in PMC

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