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Meta-Analysis
. 2015 Jul 10:5:12069.
doi: 10.1038/srep12069.

Association of three 8q24 polymorphisms with prostate cancer susceptibility: evidence from a meta-analysis with 50,854 subjects

Qiaoxin Li  1 , Xia Liu  1 , Rui-Xi Hua  2 , Feng Wang  3 , Hengqing An  3 , Wei Zhang  1 , Jin-Hong Zhu  4
Affiliations
Meta-Analysis

Association of three 8q24 polymorphisms with prostate cancer susceptibility: evidence from a meta-analysis with 50,854 subjects

Qiaoxin Li et al. Sci Rep. .

Abstract

The 8q24 polymorphisms have been implicated in various cancers. Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory. We conducted a comprehensive meta-analysis to reevaluate the associations between those polymorphisms and PCa susceptibility, according to the latest meta-analysis guidelines (PRISMA). Eligible publications were searched from MEDLINE, EMBASE and CBM. False positive report possibility analysis was performed. We totally collected 20184 cases and 20439 controls from 20 studies for the rs1447295 C>A, 1850 cases and 2090 controls from 7 studies for the rs16901979 C>A, and 12233 cases and 7582 controls from 17 studies for the rs6983267 T>G. Overall, each of studied 8q24 polymorphisms was significantly associated with PCa risk individually. Significant associations were also observed in stratified analysis by ethnicity, source of control, and quality score. Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans. The effect of rs16901979 was more prominent among Africa-Americans than Asians. Likewise, rs6983267 conferred a higher Pca risk among Caucasians than Asians. Collectively, these 8q24 variant(s) may modulate PCa risk in an ethnic-specific manner.

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Figures

Figure 1
Figure 1. Forest plots of effect estimates for 8q24-rs1447295 polymorphism and prostate cancer risk (AA+AC vs. CC).
The size of the squares indicates the relative weight of each study. Weights were derived from random-effects analysis. Bars, 95% confidence interval (CI).
Figure 2
Figure 2. Funnel plot analysis to detect publication bias for each of the 8q24 polymorphism by homozygous model.
(A) For rs1447295 polymorphism, (B) For rs16901979 polymorphism, and (C) For rs6983267 polymorphism. Each point represented an individual study for the indicated association.
Figure 3
Figure 3. Linkage disequilibrium in the 8q24 region for the previously reported polymorphisms.
Linkage disequilibrium coefficients (r2) between SNPs in the 8q24 region between 128.12 and 128.54 Mb.
Figure 4
Figure 4. Flow chart of identification of included studies.
See this image and copyright information in PMC

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