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. 2015 Jul 10:5:12035.
doi: 10.1038/srep12035.

CGMD: An integrated database of cancer genes and markers

Jangampalli Adi Pradeepkiran  1 , Sri Bhashyam Sainath  2 , Konidala Kramthi Kumar  1 , Lokanada Balasubramanyam  1 , Kodali Vidya Prabhakar  3 , Matcha Bhaskar  1
Affiliations

CGMD: An integrated database of cancer genes and markers

Jangampalli Adi Pradeepkiran et al. Sci Rep. .

Abstract

Integrating cancer genes and markers with experimental evidence might provide valuable information for the further investigation of crosstalk between tumor genes and markers in cancer biology. To achieve this objective, we developed a database known as the Cancer Gene Marker Database (CGMD), which integrates data on tumor genes and markers based on experimental evidence. The major goal of CGMD is to provide the following: 1) current systematic treatment approaches and recent advances in different cancer treatments; 2) the aggregation of different genes and markers by their molecular characteristics and pathway associations; and 3) free access to the data compiled by CGMD at http://cgmd.in/. The database consists of 309 genes and 206 markers, as well as a list of 40 different human cancers, with detailed descriptions of all characterized markers. CGMD provides complete cancer annotations and molecular descriptions of cancer genes and markers such as CpG islands, promoters, exons, PDB structures, active sites and domains.

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Figures

Figure 1
Figure 1. Web interface of the CGMD.
(A) Basic home page displaying the information in CGMD. (B) Different cancer information displayed as a list from A to Z. (C) A typical literature highlight with supporting keywords for browsing alphabetically. (D) Gene description profile. (E) Query interface. (F) Browser for various cancer pathway types. (G) KEGG pathway mapped with CGMD (color-marked). (H) Gene description list for browsing. (I) provided genome and gene features. (J) Description list types for browsing (protein-coding). (K) Provided proteomic description features. (L) Over-expressed markers list in CGMD database.
Figure 2
Figure 2. Schematic illustration of detailed integration of components associated with CGMD.
Figure 3
Figure 3. Flow-chart depicts the major aspects of CGMD database such as integration of genomic and proteomic components of different cancers.
See this image and copyright information in PMC

References

    1. Fulda S., Gorman A. M., Hori O. & Samali A. Cellular Stress Responses: Cell Survival and Cell Death. Int J Cell Biol. 214074, 23 pages (2010). - PMC - PubMed
    1. International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 43, 931–945 (2004). - PubMed
    1. Futreal P. A. et al. A census of human cancer genes. Nat Rev Cancer 4, 177–183 (2004). - PMC - PubMed
    1. Todd R. & Wong D. T. Oncogenes. Anticancer Res 19, 4729–4746 (1999). - PubMed
    1. Renan M. J. How many mutations are required for tumorigenesis? Implications from human cancer data. MolCarcinog. 7, 139–146 (1993). - PubMed

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