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. 2015:1318:149-59.
doi: 10.1007/978-1-4939-2742-5_15.

In Situ Proximity Ligation Assay (PLA)

Sonchita Bagchi  1 , Robert Fredriksson, Åsa Wallén-Mackenzie
Affiliations

In Situ Proximity Ligation Assay (PLA)

Sonchita Bagchi et al. Methods Mol Biol. 2015.

Abstract

In situ proximity ligation assay (PLA) is a method to identify physical closeness of proteins, where a signal will only be produced if the two proteins are closer than 40 nm, in tissue section or cell cultures. Modifications of the PLA method can also be used to increase specificity or sensitivity of standard immunohistochemistry protocols.

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