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. 2015:2015:461870.
doi: 10.1155/2015/461870. Epub 2015 Jun 16.

A Case of Spontaneous Tumor Lysis Syndrome in a Patient with Ovarian Cancer

Kazuhiro Okamoto  1 , Toshifumi Kinoshita  1 , Miyuki Shimizu  1 , Isoji Okura  1 , Akinori Kawada  1 , Koichi Mizobuchi  2 , Midori Ando  2
Affiliations

A Case of Spontaneous Tumor Lysis Syndrome in a Patient with Ovarian Cancer

Kazuhiro Okamoto et al. Case Rep Obstet Gynecol. 2015.

Abstract

Tumor lysis syndrome (TLS) is a potentially life-threating complication of tumors or chemotherapy treatment. TLS commonly occurs in hematological malignancies, but it is very rare in patients with a solid tumor. In cases of solid tumors, TLS usually occurs spontaneously and after the initiation of anticancer therapy, and it has a high mortality rate. We present the novel case of a 62-year-old woman with an ovarian tumor who spontaneously developed TLS. Surgical reduction of the tumor mass vastly improved her condition. She showed no sign of tumor recurrence 8 months after treatment. As TLS is life-threatening, successful treatments must be seriously considered.

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Figures

Figure 1
Figure 1
Abdominal plane computed tomography reveals a large pelvic mass with massive ascites that reach the liver and spleen. (a) Sagittal section; (b) frontal section; (c) coronal section.
Figure 2
Figure 2
Operative findings. (a) The right ovary is markedly enlarged and contains a carcinoma. (b) The large ovarian tumor is removed via a vertical midline incision after abdominal drainage is performed. (c) The excised tumor mass is 20 cm in diameter. The uterus and left ovary are macroscopically normal. (d) The tumor mass contains septations and papillary solid lesions.
Figure 3
Figure 3
Pathological findings. (a) A grade 1 endometrioid adenocarcinoma is characterized by glandular patterns resembling those of the endometrium. (b) Extensive necrosis of the endometrioid carcinoma (left side). (a-b) Hematoxylin and eosin staining (magnification, ×100).
See this image and copyright information in PMC

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