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. 1989 May-Jun;41(3):207-11.

The effect of ethanol on the antiarrhythmic action of atenolol

B Filipek  1 , J Krupińska, T Librowski, K Zebala, I Piasecka, W Piekoszewski
Affiliations
  • PMID: 2616376

The effect of ethanol on the antiarrhythmic action of atenolol

B Filipek et al. Pol J Pharmacol Pharm. 1989 May-Jun.

Abstract

The effect of ethyl alcohol on the antiarrhythmic action of atenolol in the adrenaline-induced arrhythmia model was studied in rats non-dependent and dependent on ethanol. Atenolol administered jointly with ethanol, in a single dose or repeatedly produced a weaker antiarrhythmic effect than when it was given alone. Moreover, a rise in animal mortality was observed, in particular after atenolol administration in the period of intoxication. No significant effect of atenolol on ethanol blood concentration was found.

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