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. 2015 Aug 18;51(64):12807-10.
doi: 10.1039/c5cc03951g.

Catalytic meta-selective C-H functionalization to construct quaternary carbon centres

Andrew J Paterson  1 , Sahra St John-Campbell, Mary F Mahon, Neil J Press, Christopher G Frost
Affiliations

Catalytic meta-selective C-H functionalization to construct quaternary carbon centres

Andrew J Paterson et al. Chem Commun (Camb). .

Abstract

A catalytic meta-selective C-H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C-H functionalization proceeds through a radical process directed via a remote σ-activation.

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