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. 1989 Dec;55(6):518-22.
doi: 10.1055/s-2006-962084.

[Studies on the effect of an alkaloid extract of Symphytum officinale on human lymphocyte cultures]

[Article in German]
C Behninger, G Abel, E Röder, V Neuberger, W Göggelmann

[Studies on the effect of an alkaloid extract of Symphytum officinale on human lymphocyte cultures]

[Article in German]
C Behninger et al. Planta Med. 1989 Dec.

Abstract

An alkaloid extract of Symphytum officinale was investigated for its chromosome-damaging effect in human lymphocytes in vitro. In concentrations of 1.4 micrograms/ml and 14 micrograms/ml the alkaloids had no effect, in concentrations of 140 micrograms/ml and 1400 micrograms/ml the alkaloids induced sister chromatid exchanges (SCE) as well as chromosome aberrations. Additionally, the influence of rat liver enzymes (S9) was tested. The SCE-inducing capacity and the clastogenic effect of Symphytum alkaloids was increased by simultaneous application of S9-Mix.

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