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Case Reports
. 2015 Jul-Sep;6(3):428-30.
doi: 10.4103/0976-3147.158798.

Calf heads on a trophy sign: Miyoshi myopathy

M Mundayadan Shyma  1 , P Sreedharan Roopchand  1 , K Mohan Ram  1 , C Velayudhan Shaji  1
Affiliations
Case Reports

Calf heads on a trophy sign: Miyoshi myopathy

M Mundayadan Shyma et al. J Neurosci Rural Pract. 2015 Jul-Sep.

Abstract

Miyoshi myopathy is an autosomal recessive distal myopathy with predominant involvement of the posterior calf muscles attributed to mutations in the dysferlin gene. We report a 26-year-old male, born of nonconsanginous parentage. He noticed weakness and atrophy of leg muscles with inability to walk on his heels. The creatine kinase concentration was high. The electromyography showed myopathic pattern and the muscle biopsy disclosed dystrophic changes with absence of dysferlin. Miyoshi myopathy may be distinct among the hereditary distal myopathies. There are only few reported cases of Miyoshi myopathy in the world literature. In India only 12 cases were reported who had classical features of Miyoshi myopathy. Our's is a typical case of Miyoshi myopathy, with an affected twin sister as well. He also had "calf heads on a trophy sign" on physical examination, which is considered to be pathognomonic of this disease.

Keywords: distal myopathy; familial miyoshi myopathy; “Calf heads on trophy” sign.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) Deltoid sparing; (b) scapular winging; (c) wasting of calf muscles; (d) wasting of hand muscles
Figure 2
Figure 2
Calf heads on a trophy sign. (a) Posture adopted to look for the calf heads on a trophy sign; (b) Diagrammatic representation matches with the sign shown in 2(a)
Figure 3
Figure 3
Patient with his twin sister with similar clinical appearance
See this image and copyright information in PMC

References

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