Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial
- PMID: 26170041
- DOI: 10.1016/j.jamda.2015.05.021
Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial
Abstract
Background: Age-related losses of muscle mass, strength, and function (sarcopenia) pose significant threats to physical performance, independence, and quality of life. Nutritional supplementation could positively influence aspects of sarcopenia and thereby prevent mobility disability.
Objective: To test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of sarcopenia.
Design: A multicenter, randomized, controlled, double-blind, 2 parallel-group trial among 380 sarcopenic primarily independent-living older adults with Short Physical Performance Battery (SPPB; 0-12) scores between 4 and 9, and a low skeletal muscle mass index. The active group (n = 184) received a vitamin D and leucine-enriched whey protein nutritional supplement to consume twice daily for 13 weeks. The control group (n = 196) received an iso-caloric control product to consume twice daily for 13 weeks. Primary outcomes of handgrip strength and SPPB score, and secondary outcomes of chair-stand test, gait speed, balance score, and appendicular muscle mass (by DXA) were measured at baseline, week 7, and week 13 of the intervention.
Results: Handgrip strength and SPPB improved in both groups without significant between-group differences. The active group improved more in the chair-stand test compared with the control group, between-group effect (95% confidence interval): -1.01 seconds (-1.77 to -0.19), P = .018. The active group gained more appendicular muscle mass than the control group, between-group effect: 0.17 kg (0.004-0.338), P = .045.
Conclusions: This 13-week intervention of a vitamin D and leucine-enriched whey protein oral nutritional supplement resulted in improvements in muscle mass and lower-extremity function among sarcopenic older adults. This study shows proof-of-principle that specific nutritional supplementation alone might benefit geriatric patients, especially relevant for those who are unable to exercise. These results warrant further investigations into the role of a specific nutritional supplement as part of a multimodal approach to prevent adverse outcomes among older adults at risk for disability.
Keywords: Sarcopenia; lower extremity function; muscle mass; nutritional supplementation; protein.
Copyright © 2015 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.
Similar articles
-
Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study.Clin Nutr. 2018 Apr;37(2):551-557. doi: 10.1016/j.clnu.2017.01.005. Epub 2017 Jan 17. Clin Nutr. 2018. PMID: 28132725 Clinical Trial.
-
Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.Aging Clin Exp Res. 2019 Jun;31(6):845-854. doi: 10.1007/s40520-019-01208-4. Epub 2019 May 2. Aging Clin Exp Res. 2019. PMID: 31049877 Free PMC article. Clinical Trial.
-
A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial.Clin Nutr. 2019 Feb;38(1):159-164. doi: 10.1016/j.clnu.2017.12.020. Epub 2018 Jan 9. Clin Nutr. 2019. PMID: 29395372 Clinical Trial.
-
Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis.Nutrients. 2023 Jan 19;15(3):521. doi: 10.3390/nu15030521. Nutrients. 2023. PMID: 36771225 Free PMC article.
-
Whey Protein, Leucine- and Vitamin-D-Enriched Oral Nutritional Supplementation for the Treatment of Sarcopenia.Nutrients. 2022 Apr 6;14(7):1524. doi: 10.3390/nu14071524. Nutrients. 2022. PMID: 35406137 Free PMC article. Review.
Cited by
-
The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging.Clin Interv Aging. 2022 Aug 22;17:1275-1295. doi: 10.2147/CIA.S376668. eCollection 2022. Clin Interv Aging. 2022. PMID: 36033236 Free PMC article. Review.
-
Anabolic Strategies for ICU-Acquired Weakness. What Can We Learn from Bodybuilders?Nutrients. 2024 Jun 25;16(13):2011. doi: 10.3390/nu16132011. Nutrients. 2024. PMID: 38999759 Free PMC article. Review.
-
Protein Intake and Muscle Health in Old Age: From Biological Plausibility to Clinical Evidence.Nutrients. 2016 May 14;8(5):295. doi: 10.3390/nu8050295. Nutrients. 2016. PMID: 27187465 Free PMC article. Review.
-
Beneficial Effects of Leucine Supplementation on Criteria for Sarcopenia: A Systematic Review.Nutrients. 2019 Oct 17;11(10):2504. doi: 10.3390/nu11102504. Nutrients. 2019. PMID: 31627427 Free PMC article.
-
Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy.Cancer Med. 2019 Nov;8(16):6923-6932. doi: 10.1002/cam4.2517. Epub 2019 Sep 30. Cancer Med. 2019. PMID: 31568698 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical