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. 2015 Jul;10(1):449-452.
doi: 10.3892/ol.2015.3167. Epub 2015 Apr 30.

Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression

Chunhua Lin  1 , Jitao Wu  2 , Zhenli Gao  2 , Guimei Qu  3 , Wei Wang  3 , Guohua Yu  3
Affiliations

Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression

Chunhua Lin et al. Oncol Lett. 2015 Jul.

Abstract

Primary carcinoid tumors are uncommon neoplasms in the kidney. The current study presents a case of primary carcinoid tumor of the kidney in a 49-year-old female who suffered from painless gross hematuria for half a month. Left hydronephrosis, a horseshoe kidney and a space-occupying lesion of the left ureter were found by abdominal computed tomography scans and ultrasonic testing. Surgery was performed and an oval tumor was found under the left ureter; the tumor and left kidney were excised completely. The neoplasm was composed of solid nests of cells, trabeculae, adenoid structures and anastomosing cords in a loose and myxoid background. The tumor cells, which were consistent in volume, exhibited centrally oval nuclei with inconspicuous nucleoli, and eosinophilic finely granular cytoplasm. Upon immunohistochemical staining, the neoplastic cells were positive for AE1/AE3, vimentin, synaptophysin, chromogranin A, estrogen receptor and progesterone receptor, while being negative for epithelial membrane antigen, inhibin A, cluster of differentiation (CD)99, S-100 and CD10. Based on the histological characteristics, a diagnosis of primary carcinoid tumor of the left kidney was formed. The patient did not receive further treatment. The total follow-up period was 18 months after the surgery and repeated imaging examinations every 6 months revealed no recurrence.

Keywords: carcinoid; estrogen receptor; kidney; progesterone receptor; renal tumor.

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Figures

Figure 1.
Figure 1.
(A) Ultrasonic examination revealing left hydronephrosis and a space-occupying lesion in the left ureter. (B) Tumor positioned under the uterer, the with a volume of ~5×4×3.6 cm. The boundaries of the mass were clear and the section was faintly yellow.
Figure 2.
Figure 2.
(A) Tumor was located under the mucosa of the pelvis and the neoplasm was composed of solid nests of cells, trabeculae, adenoid structures and anastomosing cords in a loose and myxoid background (hematoxylin and eosin staining; magnification, x100). (B) Neoplastic cells were similar in size and exhibited centrally placed oval nuclei with eosinophilic finely granular cytoplasm, and a low mitotic rate (hematoxylin and eosin staining; magnification, x200).
Figure 3.
Figure 3.
Immunostaining of the tumor. The tumor cells were positive for (A) synaptophysin (magnification, x200), (B) estrogen receptor (magnification, x100) and (C) progesterone receptor (magnification, x100).
See this image and copyright information in PMC

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References

    1. Han X, Yu L, Yang S, Zheng J. Primary neuroendocrine tumor of the testis: A study of clinicopathological features. Int J Clin Exp Pathol. 2014;7:1771–1776. - PMC - PubMed
    1. Kaplan AL, Margolis DJ, Said J, Chin AI. Primary carcinoid tumor of urinary bladder discovered on pelvic magnetic resonance imaging. Urology. 2012;80:e55–57. doi: 10.1016/j.urology.2012.08.009. - DOI - PubMed
    1. Pavel M, Hörsch D, Caplin M, et al. Telotristat etiprate for carcinoid syndrome: A single-arm, multicenter trial. J Clin Endocrinol Metab. 2015;100:1511–1519. doi: 10.1210/jc.2014-2247. - DOI - PubMed
    1. Chi Y, Du F, Zhao H, Wang JW, Cai JQ. Characteristics and long-term prognosis of patients with rectal neuroendocrine tumors. World J Gastroenterol. 2014;20:16252–16257. - PMC - PubMed
    1. Roy S, Hooda S, Huang GJ, Pantanowitz L, Parwani AV. A novel case of concurrent renal tumors: chromophobe renal cell carcinoma and carcinoid tumor of the kidney with brief review of renal neuroendocrine tumors. Int J Surg Pathol. 2012;20:531–535. doi: 10.1177/1066896912438588. - DOI - PubMed

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