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. 2015 Jul;10(1):453-458.
doi: 10.3892/ol.2015.3202. Epub 2015 May 12.

Clinical characteristics of acute lymphoblastic leukemia in male and female patients: A retrospective analysis of 705 patients

Su-Yi Li  1 , Jie-Yu Ye  2 , Fan-Yi Meng  2 , Chun-Fu Li  3 , M O Yang  2
Affiliations

Clinical characteristics of acute lymphoblastic leukemia in male and female patients: A retrospective analysis of 705 patients

Su-Yi Li et al. Oncol Lett. 2015 Jul.

Abstract

The aim of the present study was to compare the clinical characteristics of acute lymphoblastic leukemia (ALL) that occurred in male and female patients at one institution in Southern China. The medical electronic records of Nanfang Hospital, affiliated to Southern Medical University, were searched for patients with a definite diagnosis of ALL that were diagnosed between January 1, 2001 and December 31, 2012. The clinical data of the patients were collected and analyzed. A total of 705 eligible patients were identified. The gender ratio of male to female patients was 1.84:1. The average ages at the time of diagnosis were 16.43 and 19.54 years for male and female patients, respectively (P=0.007). No significant differences were identified in the seasonal occurrence distribution, blood group distribution or ratio for the presence of the Ph chromosome between males and females. However, a higher incidence of T-cell type ALL was identified in males (P=0.023). The present study reveals that ALL demonstrates a male predominance, but similar clinical characteristics of ALL are present in males and females in Southern China.

Keywords: acute lymphoblastic leukemia; clinical characteristics; retrospective analysis.

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Figures

Figure 1.
Figure 1.
Flow chart of the process of study selection based on eligibility.
Figure 2.
Figure 2.
Age distribution of all acute lymphoblastic leukemia patients at the time of the initial diagnosis.
Figure 3.
Figure 3.
Month distribution of the initial appearance of acute lymphoblastic leukemia symptoms.
See this image and copyright information in PMC

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