Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Spring;8(Suppl 1):S15-22.

Genetic and molecular aspects of Helicobacter pylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma

Mohammad Shadifar  1 , Ramin Ataee  2 , Amin Ataie  3 , Ali Morad Heydari Gorgi  4 , Nafiseh Nasri Nasrabadi  5 , Somayyeh Nouri  6
Affiliations
Review

Genetic and molecular aspects of Helicobacter pylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma

Mohammad Shadifar et al. Gastroenterol Hepatol Bed Bench. 2015 Spring.

Abstract

Gastric adenocarcinoma is one of the most common malignancies worldwide. Many ethological causes have been introduced among which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. This agent is also associated with different digestive diseases, such as gastritis, peptic ulcer, and mucosa-associated lymphoid tissue lymphoma. Recently, scientists have been described some molecular aspects that show the role of some apoptotic genes and proteins; for example: P53, Bcl2, C-Myc and Rb-suppressor systems in the H. pylori pathogenesis. Also the relationship between nitric oxide (NOSi genotype) with H. pylori infection has been shown. The aim of this mini-review is to explain better these genetically aspects of H.pylori pathogenesis.

Keywords: Apoptosis; C-Myc; Gastritis; Helicobacter pylori; P53.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Helicobacter pylori and possible outcomes of infection (43)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Masaaki K, Kazunari M, Tadayoshi O. Expression of mutant type-p53 products in H pylori-associated chronic gastritis. World J Gastroenterol. 2007;13:1541–46. - PMC - PubMed
    1. ZhuY , Shu X, Chen J. Effect of Helicobacter pylori eradication on oncogenes and cell proliferation. Eur J Clin Invest. 2008;38:628–33. - PubMed
    1. Nardone G, Staibano S, Rocco A. Effect of Helicobacter pylori infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis. Gut. 1999;44:789–99. - PMC - PubMed
    1. Linpisarn S, Suwan W, Lertprasertsuk N, Koosirirat C, Steger F, Prommuangyong H, et al. Helicobacter pylori caga, vaca and icea genotypes in northern thai patients with gastric disease. Southeast Asian J Trop Med Public Health. 2007;38:356–62. - PubMed
    1. Liang-jinW , Shu-jie C, Zhe C. Morphological and pathologic changes of experimental chronic atrophic gastritis (CAG) and the regulating mechanism of protein expression in rats. J Zhejiang Univ Sci B. 2006;7:634–40. - PMC - PubMed

LinkOut - more resources