Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep;46(9):2661-4.
doi: 10.1161/STROKEAHA.115.009475. Epub 2015 Jul 14.

White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline

Marije R Benedictus  1 , Argonde C van Harten  2 , Annebet E Leeuwis  2 , Teddy Koene  2 , Philip Scheltens  2 , Frederik Barkhof  2 , Niels D Prins  2 , Wiesje M van der Flier  2
Affiliations

White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline

Marije R Benedictus et al. Stroke. 2015 Sep.

Abstract

Background and purpose: In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline.

Methods: We included 334 patients with subjective cognitive decline. Follow-up was 3±2 years.

Results: Fifty-three (16%) patients progressed clinically to mild cognitive impairment or dementia. White matter hyperintensities were associated with clinical progression and with annual decline on memory, attention, executive functioning, and global cognition. Microbleeds and lacunes were not associated with clinical progression or cognitive decline.

Conclusions: In patients with subjective cognitive decline, patients with white matter hyperintensities are at increased risk of clinical progression and cognitive decline.

Keywords: cognitive decline; small vessel disease; subjective complaints; vascular cognitive impairment; white matter lesions.

PubMed Disclaimer

Publication types