Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul 15:5:11684.
doi: 10.1038/srep11684.

Biomarkers of delayed graft function as a form of acute kidney injury in kidney transplantation

Jolanta Malyszko  1 , Ewelina Lukaszyk  1 , Irena Glowinska  1 , Magdalena Durlik  2
Affiliations

Biomarkers of delayed graft function as a form of acute kidney injury in kidney transplantation

Jolanta Malyszko et al. Sci Rep. .

Abstract

Renal transplantation ensures distinct advantages for patients with end-stage kidney disease. However, in some cases early complications can lead to allograft dysfunction and consequently graft loss. One of the most common early complications after kidney transplantation is delayed graft function (DGF). Unfortunately there is no effective treatment for DGF, however early diagnosis of DGF and therapeutic intervention (eg modification of immunosuppression) may improve outcome. Therefore, markers of acute kidney injury are required. Creatinine is a poor biomarker for kidney injury due principally to its inability to help diagnose early acute renal failure and complete inability to help differentiate among its various causes. Different urinary and serum proteins have been intensively investigated as possible biomarkers in this setting. There are promising candidate biomarkers with the ability to detect DGF. We focused on emerging biomarkers of DGF with NGAL is being the most studied followed by KIM-1, L-FABP, IL-18, and others. However, large randomized studies are needed to establish the value of new, promising biomarkers, in DGF diagnosis, prognosis and its cost-effectiveness.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Novel biomarkers indicative of acute kidney injury.
Figure 2
Figure 2. Time course of novel urinary biomarkers.
See this image and copyright information in PMC

References

    1. Simi A. & Sheerin N. S. Biomarkers of acute injury: predicting the long-term outcome after transplantation. Kidney Int. 84, 1072–1074 (2013). - PubMed
    1. Saidi R. F. et al. Outcome of kidney transplantation using expanded criteria donors and donation after cardiac death kidneys: realities and costs. Am. J. Transplant. 7, 2769 (2007). - PubMed
    1. Siedlecki A., Irishb W. & Brennan D. C. Delayed graft function in the kidney transplant. Am. J. Transplant. 11, 2279–2296 (2011). - PMC - PubMed
    1. Keitel E. et al. Renal transplants using expanded cadaver donor criteria. Ann. Transplant. 9, 23–24 (2004). - PubMed
    1. Yarlagadda S. G. et al. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrol. Dial. Transplant. 24, 1039–1047 (2009). - PubMed

MeSH terms