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Comment
. 2015 Jul 13;28(1):7-9.
doi: 10.1016/j.ccell.2015.06.008.

Spleen Tyrosine Kinase Confers Paclitaxel Resistance in Ovarian Cancer

Wei Wei  1 , Michael J Birrer  2
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Spleen Tyrosine Kinase Confers Paclitaxel Resistance in Ovarian Cancer

Wei Wei et al. Cancer Cell. .
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Abstract

Adaptive chemoresistance and consequent tumor recurrence present major obstacles to the improvement of the prognosis and quality-of-life of patients with advanced-stage ovarian cancer. In this issue of Cancer Cell, Yu and colleagues describe the critical role of spleen tyrosine kinase (SYK) in paclitaxel resistance by modulating the stability of microtubules.

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