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Review
. 2015 Jun;12(2):106-16.
doi: 10.7497/j.issn.2095-3941.2015.0030.

Current approaches in treatment of triple-negative breast cancer

Hanan Ahmed Wahba  1 , Hend Ahmed El-Hadaad  1
Affiliations
Review

Current approaches in treatment of triple-negative breast cancer

Hanan Ahmed Wahba et al. Cancer Biol Med. 2015 Jun.

Abstract

Triple-negative breast cancer (TNBC) is diagnosed more frequently in younger and premenopausal women and is highly prevalent in African American women. TNBC is a term derived from tumors that are characterized by the absence of ER, PgR, and HER2. So patients with TNBC do not benefit from hormonal or trastuzumab-based therapies. TNBCs are biologically aggressive, although some reports suggest that they respond to chemotherapy better than other types of breast cancer, prognosis remains poor. This is due to: shortened disease-free interval in the adjuvant and neoadjuvant setting and a more aggressive course in the metastatic setting.

Keywords: Breast cancer; HER2; triple-negative.

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Conflict of interest statement

No potential conflicts of interest are disclosed.

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