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. 2015 Jun 15:5:304.
doi: 10.7916/D84M93KR. eCollection 2015.

Tremor and Klinefelter's Syndrome

Marcie L Rabin  1 , Shivam Om Mittal  2 , Bahman Jabbari  3
Affiliations

Tremor and Klinefelter's Syndrome

Marcie L Rabin et al. Tremor Other Hyperkinet Mov (N Y). .

Abstract

Background: Klinefelter's syndrome (KS) has been associated with tremor, but reports on tremor phenomenology and treatment are limited.

Case reports: Patient 1 is a 17-year-old male with a dystonic tremor treated with deep brain stimulation (DBS). Patient 2 is a 57-year-old male with a predominant left hand resting tremor and dystonic features.

Discussion: Our cases suggest that the tremor in patients with KS may be dystonic in nature. Patient 1 is also the third reported case of successful treatment with DBS. These cases have implications for elucidating the underlying neurobiological mechanism of tremor and identifying treatment options.

Keywords: 47, XXY; Klinefelter’s; Tremor; deep brain stimulation (DBS); dystonia; sex chromosome.

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Conflict of interest statement

Financial Disclosures: Marcie Rabin: Speaker’s Bureau for Allergan and Teva and research support from Ipsen. Shivam Mittal: None. Bahman Jabbari: Advisory board and received research grants from Allergan and Merz.

Conflict of Interests: The authors report no conflict of interest.

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