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Review
. 2015 Oct;19(10):2324-8.
doi: 10.1111/jcmm.12633. Epub 2015 Jul 14.

Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity

Jun Gu  1   2 , Wei Hu  2 , Da-dong Zhang  2
Affiliations
Review

Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity

Jun Gu et al. J Cell Mol Med. 2015 Oct.

Abstract

Doxorubicin is the mainstay of treatment for various haematological malignancies and solid tumours. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve various signalling pathways including free radical generation, peroxynitrite formation, calcium overloading, mitochondrial dysfunction and alteration in apoptosis and autophagy. Interestingly, the use of resveratrol in combination with doxorubicin has been reported to prevent cardiac toxicity as well as to exert a synergistic effect against tumour cells both in vivo and in vitro. Thus, the aim of this review is to summarize current knowledge and to elucidate the protective effect of resveratrol in doxorubicin-induced cardiotoxicity.

Keywords: ROS; apoptosis; autophagy; cardiotoxicity; doxorubicin; resveratrol.

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Figures

Figure 1
Figure 1
Proposed mechanisms of resveratrol protecting against doxorubicin-induced cardiotoxicity.
See this image and copyright information in PMC

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