[The morphofunctional damage to the biomembranes in the lipid peroxidation syndrome in patients with the terminal stage of chronic kidney failure]

Abstract

A total of 43 patients with a terminal stage of chronic renal failure (TCRF) who were on planned hemodialysis 8-12 hrs per week were studied for the status of lipid peroxidation, antioxidative system (AOS) as well as for the morphological and functional status of biological membranes. The study revealed high levels of lipid peroxidation featured by increased contents of malonic dialdehyde (MDA) and diene conjugates in the blood serum and red cells of the uremic patients. Besides, the functional incompetence of a nonenzymatic part of the AOS resulting in a decrease in the number of sulfhydryl groups in the red cells and alphatocopherol in the plasma was documented. It was suggested that intense peroxidation of lipids could lead to morphological and functional instability of biological membranes in the TCRF patients that was evidenced by high peroxide hemolysis in the red cells and disordered osmotic resistance and deformability of erythrocytes. An active MDA clearance was revealed in hemodialysis. The use of antioxidants and membraneous protectors in the treatment of the TCRF patients was found to be mandatory when high lipid peroxidation was identified.