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. 2015 Jul-Aug;53(4):422-9.

[Hematological changes induced by erythrocytapheresis]

[Article in Spanish]
Sindy Karina Ibeth Domínguez-Morales  1 , Luis Carlos Moreno-López, Juan Manuel Gallardo, José Ramón Paniagua
Affiliations
  • PMID: 26177429
Free article

[Hematological changes induced by erythrocytapheresis]

[Article in Spanish]
Sindy Karina Ibeth Domínguez-Morales et al. Rev Med Inst Mex Seguro Soc. 2015 Jul-Aug.
Free article

Abstract
in English, Spanish

Background: Although automated cell separators (apheresis) have undergone a lot of technical refinements, the effect of the procedure on hematological indices of donors is rarely taken into account. The purpose of this study is to identify potential hematologic changes in donors undergoing erythrocytapheresis.

Methods: 30 apparently healthy adult donors were evaluated. Erythrocytapheresis procedure was performed using automated equipment. Hematologic measurements (hemoglobin, hematocrit, white blood cells counts and platelets) were analyzed before and after erythrocytapheresis in all donors.

Results: We observed a significant decrease in the donors in hemoglobin (p <0.0001), hematocrit (p <0.0001), leukocytes (p <0.0001), lymphocytes (p = 0.0267), and platelets (p <0.0001). On the other hand, we found no changes in segmented, monocytes, eosinophils and basophils post erythrocytapheresis.

Conclusion: In this study we found a significant drop in complete blood count in blood donation procedure by erythrocytapheresis; there are hematological changes in both red and white cells in all donors; however, none of donors manifested symptoms of thrombocytopenia or anemia. This study demonstrates hematological changes post-donation and therefore requires larger multicenter studies, in order to establish guidelines for donors' safety in apheresis and also help in assessing donor suitability, especially given the present trend of double product apheresis collections.

Introducción: El efecto del procedimiento en los índices hematológicos del donador rara vez se determina al finalizar una sesión de donación. El propósito de este estudio es identificar las posibles alteraciones hematológicas en los donadores sometidos a eritroféresis. Métodos: Se evaluaron 30 donadores adultos, aparentemente sanos. El procedimiento de eritroféresis se realizó utilizando un equipo automatizado. Las mediciones hematológicas (hemoglobina, hematocrito, células blancas y plaquetas) se realizaron antes y después de la eritroféresis. Resultados: Existe disminución significativa en hemoglobina (p < 0.0001), hematocrito (p < 0.0001), leucocitos totales (p < 0.0001), linfocitos (p = 0.0267), y plaquetas (p < 0.0001) tras el procedimiento de donación. Por otro lado, los segmentados tienen un ligero aumento. No se encontraron cambios en monocitos, eosinófilos ni en basófilos poseritroféresis. Conclusiones: durante el procedimiento de donación sanguínea mediante eritroféresis se producen cambios hematológicos tanto en la formula roja como blanca en los donadores estudiados, a pesar de ello, ninguno de los donadores manifestaron signos de trombocitopenia o anemia. Este trabajo demuestra que existen cambios hematológicos postdonación y por ello se requiere de estudios amplios y multicéntricos, con el fin de establecer directrices para establecer un procedimiento seguro para el donador y mejorar la evaluación de idoneidad de los donadores.

Keywords: Blood banks; Blood component removal; Blood donors; Erythrocytes.

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