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Review
. 2015 Jul 15;6(4):397-407.
doi: 10.3945/an.114.007914. Print 2015 Jul.

Nutritional status of individuals with autism spectrum disorders: do we know enough?

Sobhana Ranjan  1 , Jennifer A Nasser  2
Affiliations
Review

Nutritional status of individuals with autism spectrum disorders: do we know enough?

Sobhana Ranjan et al. Adv Nutr. .

Abstract

The incidence of individuals with autism spectrum disorders (ASDs) is on the rise; therefore, well-timed screening is important. Given that this is a nutritionally vulnerable population, it is imperative to conduct a detailed nutritional assessment so that timely and intensive interventions can be recommended. This review article summarizes the research, focusing on the nutritional status of individuals with ASDs based on their anthropometric measurements, biomarkers, and dietary assessments. Research examining anthropometric measurements reveals an abnormally accelerated rate of growth among children with autism but shows inconsistent findings on the prevalence of overweight/obesity in comparison with typically growing children. Although dysregulated amino acid metabolism, increased homocysteine, and decreased folate, vitamins B-6 and B-12, and vitamin D concentrations have been proposed as possible biomarkers for an early diagnosis of ASDs, research investigating their association with age, gender, severity, and other comorbid psychiatric/nonpsychiatric disorders is lacking. There is consensus that children with autism have selective eating patterns, food neophobia, limited food repertoire, and sensory issues. Although inadequate micronutrient but adequate macronutrient intakes are increasingly reported, there are inconsistent results about the extent and type of nutrient deficiencies. Identification and development of nutritional assessment indicators that serve as early warning signs during routine practice beginning at birth and extending throughout the child's growth are necessary. With this population aging, there is also a dire need to study the adult population. A more vigorous role by nutrition professionals is warranted because management of potential comorbidities and contributory factors may be particularly problematic.

Keywords: anthropometry; autism spectrum disorders; biochemical assessment; dietary assessment; nutritional assessment; nutritional status.

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Conflict of interest statement

Author disclosures: S Ranjan and JA Nasser, no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Potential markers for screening children with autistic spectrum disorders.
See this image and copyright information in PMC

Comment in

References

    1. Autism, Developmental Disabilities Monitoring Network Surveillance Year Principal I, CDC. Prevalence of autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ 2012;61:1–19. - PubMed
    1. Bicer AH, Alsaffar AA. Body mass index, dietary intake and feeding problems of Turkish children with autism spectrum disorder (ASD). Res Dev Disabil 2013;34:3978–87. - PubMed
    1. Schreck KA, Williams K. Food preferences and factors influencing food selectivity for children with autism spectrum disorders. Res Dev Disabil 2006;27:353–63. - PubMed
    1. Nadon G, Feldman DE, Dunn W, Gisel E. Mealtime problems in children with autism spectrum disorder and their typically developing siblings: a comparison study. Autism 2011;15:98–113. - PubMed
    1. Schmitt L, Heiss CJ, Campbell EE. A comparison of nutrient intake and eating behaviors of boys with and without autism. Topics Clin Nutr 2008;23:23–31.