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Comment
. 2015 Jul 28;112(30):9150-1.
doi: 10.1073/pnas.1511568112. Epub 2015 Jul 15.

In search of the primordial actin filament

Umesh Ghoshdastider  1 , Shimin Jiang  1 , David Popp  1 , Robert C Robinson  2
Affiliations
Comment

In search of the primordial actin filament

Umesh Ghoshdastider et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Relatedness of actins. The structures of actin protofilaments (, –15) are shown below a maximum-likelihood phylogenetic tree of the actin protein sequences. The structures are aligned via the central protomer, which is shown as a ribbon (slate blue) with the nucleotide in red. The subdomains are numbered for actin. Subsequent protomers are shown as surfaces (alternating between fawn and slate blue). For dynactin, actin-related protein 1 (ARP1) is in slate blue or fawn, actin is in black, and ARP11 is in red. The number of protofilaments that comprise each filament is indicated in blue. BLAST (16) protein sequence similarities to human skeletal actin are given in red. BLAST (16) searches with the human skeletal actin sequence align less than half of each prokaryotic actin sequence.
See this image and copyright information in PMC

Comment on

References

    1. Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC. The evolution of compositionally and functionally distinct actin filaments. J Cell Sci. 2015;128(11):2009–2019. - PubMed
    1. Braun T, et al. Archaeal actin from a hyperthermophile forms a single-stranded filament. Proc Natl Acad Sci USA. 2015;112:9340–9345. - PMC - PubMed
    1. Ettema TJ, Lindås AC, Bernander R. An actin-based cytoskeleton in archaea. Mol Microbiol. 2011;80(4):1052–1061. - PubMed
    1. Yutin N, Wolf MY, Wolf YI, Koonin EV. The origins of phagocytosis and eukaryogenesis. Biol Direct. 2009;4:9. - PMC - PubMed
    1. Spang A, et al. Complex archaea that bridge the gap between prokaryotes and eukaryotes. Nature. 2015;521(7551):173–179. - PMC - PubMed

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