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Review
. 2015 Jul 16:10:107.
doi: 10.1186/s13000-015-0330-0.

Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review

Ahmed Alhumidi  1
Affiliations
Review

Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review

Ahmed Alhumidi. Diagn Pathol. .

Abstract

Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T-cell lymphoma (IVNKL) have been reported. Our case is A 47-year-old female presented with erythematous patches and plaques on the lower extremities mimicking panniculitis clinically. A skin biopsy revealed intravascular lymphoma (IVL) with a NK/T cell phenotype (positive for CD3, and granzyme B and negative for CD20, CD4, CD8, CD5). The lymphoma cells were also positive for Epstein-Barr virus by Epstein-Barr virus-encoded RNA in situ hybridization test. Because this type of lymphoma is extremely rare, our case is documented and compared with the previously reported cases.

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Figures

Fig. 1
Fig. 1
Scanning view of the cutaneous lesion revealing subcutaneous abnormal obstructed vessels (H/E, ×20)
Fig. 2
Fig. 2
Higher magnification showing distended vessels containing atypical lymphoid cells with focal fibrin thrombi (H/E, ×400)
Fig. 3
Fig. 3
The intravascular lymphoma cells were CD3+ (a), granzyme B b. and negative for CD20 (c) (immunoperoxidase hematoxylin counterstain; ×200)
Fig. 4
Fig. 4
The lymphoma cells were positive for EBV by EBV-encoded RNA in situ hybridization study (in situ hybridization ×200)
See this image and copyright information in PMC

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