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Case Reports
. 2015 Jul 16:13:216.
doi: 10.1186/s12957-015-0634-2.

Tongue cancer with mental retardation due to microcephaly: a clinical report

Akifumi Enomoto  1 , Takanori Nakatani  2 , Eri Morikage  3 , Takeshi Shimoide  4 , Suguru Hamada  5
Affiliations
Case Reports

Tongue cancer with mental retardation due to microcephaly: a clinical report

Akifumi Enomoto et al. World J Surg Oncol. .

Abstract

Oral cancer in patients with mental retardation has not been reported in detail, although the literature on clinical management of oral malignancies in the general population is extensive. No clear consensus has been established regarding the management of oral cancer in patients with mental retardation. We present herein the case of a 32-year-old Japanese man with mental retardation due to microcephaly who presented with advanced tongue cancer. He was treated with three courses of chemotherapy using superselective intra-arterial infusion of cisplatin at 100 mg/m2 via the femoral artery (Seldinger method). No major complications were encountered, and complete response was achieved. The patient has shown no clinical or radiological evidence of local recurrence or distant metastases as of 22 months after the end of treatment. This case provides a basis for the future appropriate management of oral cancer in patients with mental retardation.

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Figures

Fig. 1
Fig. 1
Intraoral findings. Intraoral photographs at initial presentation (a) and at 22 months after treatment (b). Advanced cancer is seen in the left lateral tongue with marked swelling
Fig. 2
Fig. 2
MRI assessment at initial examination. STIR (a) and contrast-enhanced T1-weighted imaging (b) on initial presentation show a prominent hyperintense lesion in the left tongue
Fig. 3
Fig. 3
MRI assessment after treatment. STIR (a) and contrast-enhanced T1-weighted imaging (b) at 22 months after treatment show no apparent abnormal lesion in the corresponding area
See this image and copyright information in PMC

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