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. 2015 Jul 15;7(296):296fs29.
doi: 10.1126/scitranslmed.aac8319.

Delineating cancer evolution with single-cell sequencing

Nicholas E Navin  1
Affiliations

Delineating cancer evolution with single-cell sequencing

Nicholas E Navin. Sci Transl Med. .

Abstract

Single-cell sequencing methods are revolutionizing cancer research and medicine by providing powerful tools to investigate intratumor heterogeneity and rare subpopulations.

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Figures

Fig. 1
Fig. 1. No tumor cells are identical
Whole-genome single cell sequencing of 4 tumor cells from an estrogen-receptor positive breast cancer patient shows that no two tumor cells are genetically identical. Clonal mutations are shown in black, subclonal mutations in intergenic regions are colored in red, and subclonal mutations in exonic regions are shown in green.
See this image and copyright information in PMC

References

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