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Review
. 2015:2015:392169.
doi: 10.1155/2015/392169. Epub 2015 Jun 9.

Resveratrol: A Focus on Several Neurodegenerative Diseases

Ester Tellone  1 , Antonio Galtieri  1 , Annamaria Russo  1 , Bruno Giardina  2 , Silvana Ficarra  1
Affiliations
Review

Resveratrol: A Focus on Several Neurodegenerative Diseases

Ester Tellone et al. Oxid Med Cell Longev. 2015.

Abstract

Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

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Figures

Figure 1
Figure 1
Biosynthetic pathway of RV.
Figure 2
Figure 2
Antioxidant activity of RV against ROS.
Figure 3
Figure 3
RV and neurodegenerative disease.
Figure 4
Figure 4
Main effects of RV.
Figure 5
Figure 5
Global representation of RV targets in neurodegenerative protection.
See this image and copyright information in PMC

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