DNA damage and repair regulate neuronal gene expression

Yijing Su^{1

2}, Guo-li Ming^{1

2

3

4}, Hongjun Song^{1

2

3}

Affiliations

¹ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³ The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁴ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

PMID: 26183066
PMCID: PMC4559811
DOI: 10.1038/cr.2015.85

Comment

DNA damage and repair regulate neuronal gene expression

Yijing Su et al. Cell Res. 2015 Sep.

. 2015 Sep;25(9):993-4.

doi: 10.1038/cr.2015.85. Epub 2015 Jul 17.

Authors

Yijing Su^{1

2}, Guo-li Ming^{1

2

3

4}, Hongjun Song^{1

2

3}

Affiliations

¹ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³ The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁴ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

PMID: 26183066
PMCID: PMC4559811
DOI: 10.1038/cr.2015.85

Abstract

Neuronal activity-induced gene expression is crucial for the development and plasticity of the brain and for learning and memory. In a recent study published in Cell, Madabhushi et al. report that neuronal activity triggers the formation of DNA double-strand breaks on promoters of early response genes, which in turn controls their expression in neurons.

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Figures

**Figure 1**
Neuronal activity-induced DNA damage and repair regulates expression of both early response and later response genes in neurons. Topo IIβ: Topoisomerase IIβ DSBs: Double strand breaks; TET: Ten-eleven translocation methylcytosine dioxygenase; BER; base-excision repair; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; C: cytosine.

See this image and copyright information in PMC

Comment on

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes.
Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. Madabhushi R, et al. Cell. 2015 Jun 18;161(7):1592-605. doi: 10.1016/j.cell.2015.05.032. Epub 2015 Jun 4. Cell. 2015. PMID: 26052046 Free PMC article.

References

1. Madabhushi R, Pan L, Tsai LH. Neuron. 2014. pp. 266–282. - PMC - PubMed
1. McKinnon PJ. Nat Neurosci. 2013. pp. 1523–1529. - PMC - PubMed
1. Kennedy RD, D'Andrea AD. J Clin Oncol. 2006. pp. 3799–3808. - PubMed
1. Suberbielle E, Sanchez PE, Kravitz AV, et al. Nat Neurosci. 2013. pp. 613–621. - PMC - PubMed
1. Madabhushi R, Gao F, Pfenning AR, et al. Cell. 2015. pp. 1592–1605. - PMC - PubMed

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DNA damage and repair regulate neuronal gene expression

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DNA damage and repair regulate neuronal gene expression

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