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. 2015 Nov 1;172(11):1064-6.
doi: 10.1176/appi.ajp.2015.14121537. Epub 2015 Jul 17.

Ketamine inside neurons?

Henry A Lester  1 , Luke D Lavis  1 , Dennis A Dougherty  1
Affiliations

Ketamine inside neurons?

Henry A Lester et al. Am J Psychiatry. .
No abstract available

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Figures

FIGURE 1.
FIGURE 1.. One Expects Ketamine to Accumulate in Acidic Vesicles of Any Living Cella
a ket+ = protonated ketamine concentration in organelles; ketCSF=ketamine concentration in CSF. The colors represent pH in cytoplasm and within organelles. The ratios are based on calculations by Trapp (22). That weakly basic psychiatric drugs accumulate in acidic vesicles, by a factor of 50–100, within neurons has been elegantly proven (23).
See this image and copyright information in PMC

References

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    1. Zarate CA Jr, Mathews D, Ibrahim L, et al.: A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression. Biol Psychiatry 2013; 74:257–264 - PMC - PubMed
    1. Murrough JW, Iosifescu DV, Chang LC, et al.: Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry 2013; 170:1134–1142 - PMC - PubMed
    1. Glasgow N, Johnson J: Voltage dependence of NMDA receptor inhibition by memantine and by ketamine depend on duration of glutamate application and on receptor subtype, in Neuroscience Abstracts (Program No 501.08). Washington, DC, Society for Neuroscience, 2014

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