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Review
. 2015 Jul 7:9:3547-55.
doi: 10.2147/DDDT.S84850. eCollection 2015.

Dolutegravir - a review of the pharmacology, efficacy, and safety in the treatment of HIV

Christopher E Kandel  1 , Sharon L Walmsley  2
Affiliations
Review

Dolutegravir - a review of the pharmacology, efficacy, and safety in the treatment of HIV

Christopher E Kandel et al. Drug Des Devel Ther. .

Abstract

Dolutegravir is the newest integrase strand transfer inhibitor to be approved for the treatment of human immunodeficiency virus (HIV) infection. Dolutegravir is equivalent or superior to existing treatment regimens in both treatment-naïve and treatment-experienced patients including those with previous raltegravir or elvitegravir failure. The consistent efficacy coupled with excellent tolerability and infrequent drug-drug interactions makes the co-formulation of dolutegravir with two nucleotide reverse-transcriptase inhibitors an attractive treatment option. This review summarizes the pharmacokinetics, adverse event profile, and efficacy of dolutegravir in the treatment of HIV.

Keywords: antiretroviral therapy; integrase inhibitor; patient-reported outcomes.

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References

    1. Günthard HF, Aberg JA, Eron JJ, et al. International Antiviral Society-USA Panel Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014;312(4):410–425. - PubMed
    1. Warnke D, Barreto J, Temesgen Z. Antiretroviral drugs. J Clin Pharmacol. 2007;47(12):1570–1579. - PubMed
    1. Gandhi M, Gandhi RT. Single-pill combination regimens for treatment of HIV-1 infection. N Engl J Med. 2014;371(3):248–259. - PubMed
    1. Samji H, Cescon A, Hogg RS, et al. the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA Closing the gap: increases in life expectancy among HIV-positive individuals in the United States and Canada. PLoS One. 2013;8(12):e81355. - PMC - PubMed
    1. Rodger AJ, Lodwick R, Schechter M, et al. INSIGHT SMART, ESPRIT Study Groups Mortality in well controlled HIV in the continuous antiretroviral arms of the SMART and ESPRIT trials compared with the general population. AIDS. 2013;27(6):973–979. - PubMed

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